Cerebrolysin

1. Product Overview

Cerebrolysin is a biologically derived, heterogeneous peptide mixture isolated through the standardized enzymatic breakdown of purified porcine brain proteins. This preparation contains low-molecular-weight peptides and free amino acids, designed to mimic and potentially augment the activity of endogenous neurotrophic factors such as Brain-Derived Neurotrophic Factor (BDNF), Nerve Growth Factor (NGF), and Glial Cell Line-Derived Neurotrophic Factor (GDNF).

Feature

Detail

Product Name

Cerebrolysin (Porcine Brain Peptide Complex)

Origin

Biologically Derived (Porcine)

Form

Lyophilized Powder

Target Application

Research: Neuronal Survival, Synaptic Plasticity, Neuroprotection

2. Chemical and Biological Characteristics

Cerebrolysin is characterized by its complex composition, which is critical for its reported biological activities.

Composition

The active ingredients are primarily peptide fragments and free amino acids.

Component

Detail

Active Peptide Fragments

Molecular Weight < 10 kDa

Amino Acids

Presence of essential and non-essential free amino acids

Solvents/Additives

None (Lyophilized Powder)

Mechanism of Action (Research Focus)

Studies suggest that the components within Cerebrolysin influence multiple intracellular signaling pathways associated with neuronal health and repair:

1. PI3K/Akt Pathway Modulation: The complex is believed to modulate the Phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, which is integral to cell survival, anti-apoptosis, and protein synthesis.
2. MAPK/ERK Activation: It also demonstrates influence over the Mitogen-Activated Protein Kinase (MAPK)/Extracellular signal-Regulated Kinase (ERK) cascade, a pathway critical for synaptic plasticity, cell differentiation, and learning/memory processes.
3. Neurotrophic Factor Mimicry: The peptides are thought to bind to or interact with receptors typically reserved for neurotrophic factors, promoting neurite outgrowth and protecting neurons from various stressors.

3. Product Specifications and Quality Control

The following table details the key specifications verified for the current batch.

Specification Parameter

Standard

Result (Batch 2025007)

Purity (HPLC)

> 99.00%

99.42% (Batch Confirmed)

Appearance

White to Off-White Powder

Off-White Lyophilized Powder

Solubility

Soluble in Water (10 mg/mL)

Confirmed

pH (1% Solution)

6.5 - 7.5

7.1

Moisture Content (Karl Fischer)

< 3.0%

1.8%

Endotoxin Level

< 5 EU/mg

< 0.1 EU/mg

4. Batch Information

Detailed information for the current available batch is provided below for traceability and quality assurance.

Parameter

Value

Batch Number

2025007

Manufacturing Date

Date

Expiration Date

Date

Quality Control (QC) Lead

Person

Storage Conditions

Store at 2°C – 8°C, protected from light

5. Handling and Safety

Cerebrolysin is intended strictly for in vitro or in vivo research applications only.

Storage

Store the lyophilized powder at a temperature between 2°C and 8°C. Ensure the container is tightly sealed to prevent moisture absorption. Avoid repeated freeze-thaw cycles after reconstitution.

Reconstitution Protocol (General Guide)

For research use, the product is typically reconstituted in sterile water or a balanced salt solution (e.g., PBS).

Step

Detail

1

Allow the powder to reach room temperature before opening.

2

Add the desired volume of sterile solvent (e.g., 1 mL).

3

Gently swirl until fully dissolved. DO NOT SHAKE VIGOROUSLY.

4

Store reconstituted solution at 2°C – 8°C for short-term use.

Safety Data Sheet

The complete Safety Data Sheet (SDS) contains essential information regarding handling, hazards, and disposal procedures.

SDS Document: File

6. Regulatory Statement (For Research Use)

This product is for Research Use Only (RUO) and is not intended for human or animal diagnostic or therapeutic use. Researchers must follow all applicable institutional, local, state, and federal guidelines when handling and disposing of this material.References and Further Reading

For detailed insights into the preclinical and clinical studies involving Cerebrolysin and related neurotrophic peptide complexes, the following general categories of literature may be consulted:

• Neuroprotection and Ischemia: Literature focusing on the product's effect in models of stroke and traumatic brain injury.
• Neurodegenerative Diseases: Studies investigating potential applications in Alzheimer's disease, Parkinson's disease, and related dementias.
• Synaptic Plasticity and Cognition: Research articles detailing the influence of the peptide complex on learning, memory, and neurite outgrowth in vitro and in vivo.

Note: Specific references should be sourced by the end-user based on their particular research domain and regulatory requirements.

1. Ordering Information

For pricing, bulk orders, and technical support, please contact our sales and research support teams.

Parameter

Detail

Product Code

CEREB-PPC-Lyo-100mg

Standard Unit Size

100 mg Lyophilized Powder

Technical Support

[Email Address]

Sales Inquiries

[Email Address]

Lead Time (Standard)

3-5 Business Days