IGF-1 DES (1-3)

1. Product Overview and Identification

Attribute

Value

Product Name

IGF-1 DES (1-3) - Research Grade

Synonyms

Des(1-3) IGF-1, Truncated IGF-1

CAS Number

[Specific CAS Number Placeholder]

Product Code

[Product Code Placeholder]

Molecular Formula

[Molecular Formula Placeholder]

Molecular Weight

[Molecular Weight Placeholder]

2. Structure and Sequence Modification

IGF-1 DES (1-3) is a powerful, naturally occurring analog of Insulin-like Growth Factor 1 (IGF-1). It is defined by a precise structural modification that significantly enhances its biological activity in in vitro and in vivo research models.

Structure

IGF-1 DES (1-3) is a Truncated Polypeptide with the structural designation Des[1-3] IGF-1.

Sequence Modification

The modification consists of the removal of the N-terminal tripeptide sequence: Glycine (Gly) - Proline (Pro) - Glutamic Acid (Glu). This results in a peptide that is three amino acids shorter than the full-length, native IGF-1 molecule.

3. Product Description and Mechanism of Action

IGF-1 DES is valued in biomedical research for its unique pharmacological profile, which overcomes the primary limitation of native IGF-1: binding to IGF-binding proteins (IGFBPs).

Enhanced Bioactivity

The removal of the first three N-terminal amino acids () dramatically alters the peptide's binding characteristics. This truncation specifically prevents the peptide from binding effectively to the six main types of IGF-binding proteins (IGFBP-1 through IGFBP-6).

• Result: The peptide remains "free" in solution, resisting sequestration by IGFBPs. This results in significantly higher bioavailability and an overall greater percentage of the administered dose being available to interact with target receptors.

Mechanism

IGF-1 DES (1-3) functions as a potent IGF-1 Receptor Agonist. It binds to the Type 1 Insulin-like Growth Factor Receptor (IGF-1R) with high affinity, initiating intracellular signaling pathways that promote cell growth, proliferation, differentiation, and survival.

Potency

Due to its negligible affinity for IGFBPs, IGF-1 DES (1-3) exhibits a substantially increased potency, documented in some bioassays to be up to 10-fold greater than native IGF-1.

4. Specifications and Characterization

This product is manufactured under strict quality control standards to ensure high purity and research reliability.

Specification Parameter

Value

Form

Lyophilized Powder

Purity (HPLC)

>95%

Counter-ion

[Specific Counter-ion Placeholder]

Appearance

White to Off-White Powder

Solubility

Soluble in distilled water or 0.1 M acetic acid

Activity

IGF-1 Receptor Agonist (High Potency)

IGFBP Binding Affinity

Negligible

The certificate of analysis is available upon request: File.

5. Handling and Storage Guidelines

Proper handling and storage are essential for maintaining the stability and integrity of the lyophilized peptide.

Unopened Lyophilized Powder

• Temperature: Store at -20°C or below.
• Conditions: Desiccated environment, protected from light.
• Stability: Stable for up to Date years when stored properly.

Reconstitution

1. Preparation: Allow the vial to equilibrate to room temperature for at least 30 minutes before opening.
2. Solvent: Reconstitute in sterile, research-grade water or a dilute acid solution (e.g., 0.1 M Acetic Acid) to prevent aggregation.
3. Concentration: Reconstitution to a working stock concentration (typically 0.1 mg/ml to 1 mg/ml) is recommended.
4. Mixing: Gently swirl the vial to dissolve; DO NOT VORTEX.

Reconstituted Solution

• Short-Term Storage (Days): Store at 4°C for up to Date days.
• Long-Term Storage (Weeks/Months): Aliquot the solution into single-use vials to prevent repeated freeze-thaw cycles. Store aliquots at -20°C or -80°C.
• Freeze-Thaw Limit: Limit freeze-thaw cycles to a maximum of 3.

6. Safety and Usage Information

Intended Use

FOR LABORATORY RESEARCH USE ONLY.

IGF-1 DES (1-3) is strictly intended for in vitro and in vivo research applications by qualified personnel in a controlled laboratory environment.

Safety Disclaimer

This product is NOT FOR HUMAN CONSUMPTION or therapeutic use. It is NOT a drug, food, or cosmetic. Researchers must follow all applicable institutional, local, and national guidelines for the handling of potent biochemical agents. Review the Safety Data Sheet (SDS) before handling the product: File.

Required Protective Equipment

When handling the lyophilized powder or concentrated solutions, researchers should wear:

• Lab coat
• Safety glasses
• Disposable gloves

7. Related Research Applications

IGF-1 DES (1-3) is frequently used in studies investigating the biological roles of IGF-1 signaling pathways without the confounding variable of IGFBP interference.

Common research areas include:

• Muscle Hypertrophy Studies: Examining the role of IGF-1R activation in promoting muscle cell growth and regeneration.
• Cellular Metabolism: Investigating its effects on glucose uptake and insulin sensitivity in various cell lines.
• Neurological Research: Studying neurogenesis, neuroprotection, and nerve regeneration processes.
• Wound Healing and Tissue Repair Models: Researching its function in accelerating cellular repair mechanisms.

Please refer all inquiries regarding the product or technical support to Person via email at Person@researchlabs.com or by attending our technical webinar scheduled for Date Calendar event.