GHRP-2

1. Product Identification

Field

Detail

Product Name

GHRP-2 (Pralmorelin) - Research Grade

Classification

Growth Hormone Secretagogue (GHS)

Chemical Name

Growth Hormone Releasing Peptide-2

Sequence

D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2

Formula

Not specified

CAS Number

Not specified

2. General Description

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide, part of the Growth Hormone Secretagogue (GHS) family. It acts as a potent agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R), which is located primarily in the hypothalamus and pituitary gland.

It holds historical significance as the first of its class to be introduced as a test peptide for research into hormone deficiency and endocrine function. Its primary utility in laboratory settings is to investigate the mechanisms of growth hormone (GH) release.

3. Mechanism of Action

A. GHS-R Agonism

GHRP-2 functions through two main pathways to elicit a robust and dose-dependent release of Growth Hormone:

1. Direct Stimulation: It directly binds to and activates the GHS-R (specifically the GHS-R1a subtype) on somatotroph cells within the anterior pituitary gland. This activation signals the cells to synthesize and release Growth Hormone.
2. Somatostatin Suppression: A secondary but crucial action is the suppression of somatostatin (Growth Hormone Inhibiting Hormone or GHIH) at the hypothalamic level. By reducing the inhibitory feedback loop of somatostatin, GHRP-2 allows for a stronger and more sustained pulsatile release of GH.

B. Specifications

Specification

Detail

Mechanism

GHS-R Agonist / Somatostatin Inhibitor

Activity

Stimulates GH secretion; increases Insulin-like Growth Factor 1 (IGF-1)

Purity

High purity research grade (Lyophilized)

Appearance

Lyophilized powder

Solubility

Soluble in water, buffered solutions, and mild organic solvents

4. Research Applications

GHRP-2 is strictly for in vitro and in vivo laboratory research and is not intended for human or animal therapeutic use.

A. Endocrine System Studies

• GH Secretion Dynamics: Used to study the complex regulatory network controlling the release of Growth Hormone, providing insights into the mechanisms of GH pulse generation.
• Hormone Deficiency Modeling: Employed as a diagnostic or testing tool in research models of pituitary insufficiency or growth hormone deficiency (GHD).
• Ghrelin Receptor Function: It serves as a tool to map and characterize the function and distribution of the GHS-R in various tissues beyond the pituitary, including the gastrointestinal tract, heart, and immune system.

B. Metabolic and Physiological Research

The resulting increase in GH and subsequent rise in IGF-1 drive various physiological changes that are under active research:

• Body Composition Research: Investigating the role of elevated GH/IGF-1 levels in lipolysis (fat breakdown) and lean body mass accumulation in research subjects.
• Cellular Repair and Regeneration: Exploring the peptide's effects on tissue repair, collagen synthesis, and wound healing processes.
• Appetite and Energy Balance: Since it is a ghrelin receptor agonist, studies can use GHRP-2 to investigate appetite regulation, energy homeostasis, and its potential impact on caloric intake, similar to endogenous ghrelin.

5. Handling and Storage

A. Shipping and Receipt

The research-grade peptide is typically shipped as a white, lyophilized powder, stable at ambient temperatures for short periods during transit. Upon receipt, immediate inspection and proper storage are critical to maintaining product integrity.

B. Storage Conditions

1. Lyophilized State (Prior to Reconstitution): Store at -20°C or colder (e.g., -80°C) for long-term stability. The vial should be tightly sealed and protected from light and moisture.
2. Reconstituted State (After Reconstitution): Dissolved peptide is highly susceptible to degradation. Store reconstituted solutions at 2°C to 8°C (refrigerator) and use within a short period (typically 7-14 days). Avoid multiple freeze-thaw cycles if aliquoting is necessary for longer storage.

C. Reconstitution

Reconstitution should be performed using a sterile solvent. Bacteriostatic water (BW) or sterile 0.9% saline are common choices. The exact volume of solvent required depends on the desired working concentration.

• Recommended Solvents: Bacteriostatic Water for Injection (BWFI) or sterile 0.9% NaCl solution.
• Procedure: Gently add the solvent to the peptide vial. Allow the peptide to dissolve naturally without shaking or agitation, which can denature the peptide. A gentle swirling motion is acceptable.

6. Safety and Regulatory Information

A. Safety Precautions

GHRP-2 is designated as a research chemical. Standard laboratory safety practices must be observed when handling this product:

• Personal Protective Equipment (PPE): Always wear lab coats, gloves, and eye protection.
• Ventilation: Work in a well-ventilated area or chemical fume hood if handling the powder.
• Waste Disposal: Dispose of all unused material and contaminated equipment according to institutional hazardous waste protocols.

B. Regulatory Disclaimer

This product is sold FOR RESEARCH USE ONLY and is not approved for use in humans or for any diagnostic or therapeutic application. The end-user assumes all responsibility for compliance with all applicable local, state, and federal laws and regulations regarding the use of this material. The user is responsible for obtaining a copy of the Safety Data Sheet (SDS) before use.

7. Related Research Compounds

GHRP-2 is one of several growth hormone secretagogues available for research. Other related compounds often studied in parallel include:

Compound

Classification

Primary Research Focus

GHRP-6

Growth Hormone Secretagogue

Strongest effect on Ghrelin-like signaling and appetite.

Ipamorelin

Selective GHS

Highly selective for GH release with minimal effect on Prolactin or Cortisol.

CJC-1295

Growth Hormone Releasing Hormone (GHRH) Analog

Used to study sustained, long-acting GH release.

Tesamorelin

Growth Hormone Releasing Factor (GRF)

Research in metabolic and lipolytic pathways.

8. Analytical Documentation

A. Purity Analysis

As a high-purity research grade material, GHRP-2 is typically validated through rigorous analytical methods to confirm its identity and purity.

Method

Purpose

Typical Result

HPLC

High-Performance Liquid Chromatography for Purity

>98% (Specific purity lot-dependent)

MS

Mass Spectrometry for Molecular Weight

Confirms correct molecular mass for D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2

Amino Acid Analysis

Confirms sequence integrity

Confirms correct ratio of constituent amino acids

Detailed Certificate of Analysis (CoA) for the specific batch number can be obtained upon request, often found linked to the product page or within the accompanying material File.

9. Contact and Ordering Information

For technical support, inquiries regarding bulk pricing, or to request a Certificate of Analysis, please contact the supplier through the following channels:

• Technical Support Email: Person@researchlabs.com
• Ordering Hotline: Not specified
• Product ID: Not specified