BPC-157 / TB500 / GHK-Cu Blend

Product Overview

Category: Research Peptide Blend

This formulation combines three of the most extensively researched peptides—BPC-157, TB500 (Thymosin Beta-4), and GHK-Cu—into a single, stable blend. Designed to streamline laboratory protocols, this blend allows researchers to investigate synergistic pathways involved in inflammation control, tissue regeneration, and cellular aging without the logistical burden of administering multiple individual compounds.

Purity & Format: High-Purity Lyophilized Powder

Intended Use: Exclusively for in vitro and in vivo research applications. Not for human consumption or therapeutic use.

Technical Specifications

Component

Sequence (Amino Acids)

Molecular Formula

Molecular Weight (g/mol)

BPC-157

L-Valyl-Glycyl-L-Prolyl-L-Prolyl-L-Prolyl-Glycyl-L-Lysyl-L-Prolyl-L-Alanyl-L-Aspartyl-L-Aspartyl-L-Alanyl-L-Glycyl-L-Leu-L-Valine

C62H98N16O22

1419.53

TB500

Acetyl-L-Leucyl-L-Lysyl-L-Lysyl-L-Thr-L-Glu-L-Thr-L-Glutamyl-L-Lysyl-L-Asn-L-Prolyglycyl-L-Lysyl-L-Lysyl-L-Prolyl-L-Aspartyl-L-Glutamyl-L-Isoleucyl-L-Glutamyl-L-Isoleucyl-L-Glu-L-Lysyl-L-Gln-L-Ala-Gly-L-Glutamyl-L-Serine-L-Isoleucyl-L-Aspartyl-L-Lysyl-L-Leu-L-Lysyl-L-Lysyl-L-Thr-L-Glutamyl-L-Thr

C212H350N56O78

4963.44

GHK-Cu

Glycyl-L-Histidyl-L-Lysine (Copper II Complex)

C14H22N6O4Cu

400.91

Storage Conditions: Store lyophilized powder at -20°C. Once reconstituted, solutions should be stored at 2-8°C and used within Date to ensure maximum stability and activity. Avoid repeated freeze-thaw cycles.

Mechanistic Profile

BPC-157 (Body Protection Compound)

A pentadecapeptide derived from gastric protective proteins. It is noted for its rapid systemic distribution and ability to traverse the blood-brain barrier. Its primary action involves modulating the nitric oxide (NO) pathway, promoting vascular endothelial growth factor (VEGF) expression, and counteracting cytokine-induced damage.

Key mechanisms under investigation:

• Angiogenesis: Significantly promotes new blood vessel formation, which is critical for healing compromised tissue.
• Anti-inflammatory Effects: Modulates various inflammatory mediators, often exerting protective effects against acute and chronic inflammation.
• Organ Protection: Demonstrates protective effects in various organs, including the stomach, liver, and central nervous system.

TB500 (Thymosin Beta-4 Derivative)

A synthetic derivative of Thymosin Beta-4. It functions by sequestering actin to regulate cell motility and modifying gene expression patterns related to inflammation and angiogenesis.

Key mechanisms under investigation:

• Cell Migration: Accelerates the migration of various cell types, including endothelial cells, keratinocytes, and fibroblasts, which are essential for tissue repair.
• Stem Cell Differentiation: Potential role in promoting the differentiation of various precursor cells into functional tissue cells.
• Immune Response: Involved in the regulation of T-cell development and adaptive immunity.

GHK-Cu (Copper Tripeptide-1)

A copper-binding tripeptide that stimulates metalloproteinases for tissue remodeling and upregulates antioxidant enzymes like superoxide dismutase.

Key mechanisms under investigation:

• Tissue Remodeling: Stimulates the synthesis of collagen and glycosaminoglycans and regulates the activity of metalloproteinases (MMPs), which are necessary for scarless healing and tissue maintenance.
• Antioxidant Defense: Acts as a potent antioxidant by increasing the expression of protective antioxidant enzymes, reducing oxidative stress.
• Gene Modulation: Has been shown to modulate the expression of over File human genes, suggesting broad regulatory roles in health and disease.

Synergistic Research Applications

This blend is ideal for experimental models focusing on wound healing acceleration, the "inflammaging" theory of aging, and antimicrobial defense in compromised tissue. The combined mechanisms offer a comprehensive model for investigating complex biological processes:

1. Accelerated Wound Healing: BPC-157 and TB500 promote cell migration and angiogenesis, while GHK-Cu facilitates tissue remodeling and reduces scarring.
2. "Inflammaging" Studies: The blend targets chronic, low-grade inflammation (a hallmark of aging) through the anti-inflammatory actions of BPC-157 and TB500, complemented by the antioxidant and restorative properties of GHK-Cu.
3. Musculoskeletal and Joint Regeneration: Researchers can investigate the simultaneous repair of damaged muscle, tendon, and ligament tissues, capitalizing on the reparative effects of all three peptides.

Recommended Reconstitution Protocol (Example)

For optimal experimental results, follow the standard reconstitution procedure detailed in the accompanying File Protocol Guide.

A summary of the reconstitution steps is provided in the table below:

Step

Action

Notes

1

Warm the vial to room temperature.

Prevents moisture condensation.

2

Prepare a sterile solvent.

Bacteriostatic water or 0.9% saline is recommended.

3

Slowly introduce the solvent.

Use a sterile syringe to drip the solvent down the side of the vial.

4

Gently swirl.

DO NOT SHAKE. Agitation can damage the peptide structure.

5

Storage.

Store reconstituted solution at 2-8°C.

Safety and Handling

This product is for research use only. Always handle with appropriate personal protective equipment (PPE), including gloves, lab coats, and eye protection. Consult the Safety Data Sheet (File) prior to handling. Dispose of all materials according to institutional and local regulations at Place.

Ordering and Support

For bulk orders or inquiries regarding custom blend formulations, please contact Person at Date.

Related Resources

• Review Article on Peptide Synergy: File
• Upcoming Webinar on Peptide Research Methodologies: Calendar event