CJC-1295 (No DAC)

1. Product Identification

This technical data sheet provides detailed information for the research-grade peptide known as CJC-1295 (No DAC). This compound is intended strictly for in vitro and ex vivo research use only and is not for human or animal use.

Property

Value

Product Name

CJC-1295 (No DAC) - Research Grade

Synonyms

Modified GHRH (1-29) Analog, Sermorelin modified, GHRH Analog

Classification

GHRH Agonist

CAS Number

[Specific CAS Number Placeholder]

2. Chemical Structure and Characteristics

CJC-1295 (No DAC) is a highly specialized synthetic peptide designed to mimic the action of the endogenous Growth Hormone-Releasing Hormone (GHRH).

2.1. Sequence and Composition

The structure is based on the N-terminal fragment of GHRH, with modifications for stability.

Parameter

Details

Sequence

Modified GHRH (1-29) Analog

Molecular Formula

[Molecular Formula Placeholder]

Molecular Weight

[Molecular Weight Placeholder]

Amino Acids

30

2.2. Peptide Description

CJC-1295 (No DAC) is a synthetic peptide analog of Growth Hormone-Releasing Hormone (GHRH). It is composed of the first 29 amino acids of GHRH with four strategic substitutions (at positions 2, 8, 15, and 27) to enhance resistance to enzymatic degradation. The "No DAC" designation indicates the absence of the Drug Affinity Complex, resulting in a peptide that preserves the natural, pulsatile secretion pattern of Growth Hormone (GH) rather than inducing the sustained elevation seen with DAC-conjugated variants.

3. Mechanism of Action

CJC-1295 (No DAC) acts as a highly selective agonist of the Growth Hormone-Releasing Hormone Receptor (GHRHR).

Specification

Detail

Mechanism

Selectively binds to pituitary somatotrophs, activating the GHRHR.

Receptor Binding

GHRHR Agonist

Biological Effect

Stimulates the release of Growth Hormone (GH) from the anterior pituitary gland in a pulsatile manner.

Comparison to Native GHRH

Enhanced resistance to cleavage by Dipeptidyl Peptidase IV (DPP-IV) compared to native GHRH(1-44).

4. Research Specifications

This product is manufactured and provided for research purposes, meeting strict quality standards.

Feature

Specification

Purity

High purity research grade (Lyophilized).

Physical Appearance

White or off-white lyophilized powder.

Storage (Lyophilized)

Recommended storage at -20°C to -80°C.

Reconstitution Solvent

Sterile Bacteriostatic Water or 0.9% NaCl solution.

Storage (Reconstituted)

Short-term storage (2-8°C); Long-term storage (-20°C or colder).

Analysis Documentation

[Certificate of Analysis (CoA) file placeholder] and [HPLC and Mass Spectrometry data file placeholder] are available upon request.

5. Handling and Safety Information

5.1. General Handling

Researchers should adhere to standard laboratory practices when handling this material.

• Wear appropriate Personal Protective Equipment (PPE), including laboratory coats, gloves, and eye protection.
• Handle under a chemical fume hood where appropriate to minimize exposure to airborne particulates during weighing or reconstitution.

5.2. Safety Precautions

This product is sold for research use only and has not been tested for safety and efficacy in humans.

Safety Topic

Instruction

Exposure

In case of accidental exposure, seek immediate medical attention and consult the Safety Data Sheet (SDS).

Disposal

Dispose of according to local, state, and federal regulations for biological and chemical waste.

Spills

Contain and clean up spills using appropriate absorbent materials.

6. Stability and Shelf Life

The stability of CJC-1295 (No DAC) is highly dependent on proper storage conditions.

6.1. Lyophilized Powder

The product is most stable in its lyophilized form.

• Long-Term Storage: Date to Date at -20°C or colder.

6.2. Reconstituted Solution

The stability of the solution is significantly reduced after reconstitution.

• Avoid repeated freeze-thaw cycles.
• Maximum Recommended Storage Period (Refrigerated): Date (at 2-8°C).

7. Experimental Use and Protocols

CJC-1295 (No DAC) is a valuable tool for studying the regulation of growth hormone secretion and the effects of GHRH analogs in vitro.

7.1. Reconstitution Protocol

1. Allow the vial of CJC-1295 (No DAC) to reach room temperature before opening.
2. Slowly add the desired volume of sterile solvent (e.g., Bacteriostatic Water) to the vial, washing down the sides.
3. Do not shake. Gently swirl the vial until the peptide is fully dissolved.
4. Once reconstituted, the solution may be aliquoted and frozen for long-term storage or refrigerated for immediate use.

7.2. Recommended Research Applications

• Studies on pituitary somatotroph function and signaling pathways.
• Investigating the pulsatile release mechanism of Growth Hormone.
• Comparative studies against other GHRH analogs or Sermorelin.
• Development of in vitro assays for GHRHR activity.

8. Ordering and Support Information

For questions regarding product availability, bulk ordering, or technical support, please contact Person at [Support Email Address Placeholder] or [Support Phone Number Placeholder].

Contact Type

Detail

Technical Support

Person

Research Inquiries

[General Inquiries Email Placeholder]

Location

Place

9. Disclaimer

CJC-1295 (No DAC) is offered strictly as a research grade material. It is not intended for use as a drug, food additive, cosmetic, or household chemical. The purchaser assumes all responsibility for handling and use in accordance with standard laboratory practices and all applicable regulations. The seller warrants that the product conforms to the chemical description on this label. The seller makes no other warranties, express or implied, including the implied warranties of merchantability and fitness for a particular purpose.