BPC-157

1. Product Identification

Product Name

BPC-157 (Pentadecapeptide) - Research Grade

Sequence Origin

Human Gastric Juice Protein Derivative

CAS Number

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Molecular Formula

C62H98N16O22

Purity

>98% (HPLC)

Format

Lyophilized powder

Storage

Recommended: -20°C for long term; Short term: 2-8°C

2. Description and Mechanism of Action

BPC-157 is a synthetic pentadecapeptide, a short chain consisting of 15 amino acids, with the sequence G E P P G K P E Q P A X A G, where X represents a specific amino acid. It is derived from the larger Body Protection Compound (BPC) protein, which is naturally occurring in the human digestive tract (gastric juice).

In laboratory settings, BPC-157 has demonstrated an exceptional ability to retain and amplify the cytoprotective and healing properties of its parent molecule. This peptide is extensively investigated for its pleiotropic effects on physiology, suggesting multiple pathways for its observed biological activity.

Proposed Mechanisms:

• Nitric Oxide (NO) System Regulation: BPC-157 is hypothesized to regulate the Nitric Oxide (NO) system, influencing both NO synthesis and NO release. This regulatory action is critical for modulating vascular tone, blood flow, and tissue oxygenation, which are all fundamental to the healing process.
• VEGFR2 Activation: Research suggests BPC-157 promotes blood vessel growth (angiogenesis) by stimulating the Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) pathway. This is a critical mechanism in repairing damaged tissues, ensuring a new supply of oxygen and nutrients.
• FGF and TGF-β Modulation: It may interact with growth factors like Fibroblast Growth Factor (FGF) and Transforming Growth Factor-beta (TGF-β), crucial players in cellular proliferation, differentiation, and extracellular matrix (ECM) synthesis.
• Anti-Inflammatory Effects: Studies show BPC-157 may modulate inflammatory mediators, reducing tissue damage and accelerating the transition from the inflammatory phase to the proliferative phase of wound healing.

3. Key Research Areas

The broad spectrum of biological activity associated with BPC-157 makes it a subject of intensive study across multiple domains of tissue repair and cytoprotection.

3.1. Wound Healing

The most well-documented area of research involves BPC-157's profound effect on tissue regeneration. It accelerates the healing of various types of wounds, including skin, muscle, tendon, ligament, and bone injuries.

• Tendon and Ligament Repair: Stimulates the proliferation and migration of fibroblasts, crucial for laying down the collagen matrix required for structural repair.
• Muscle Regeneration: Promotes the rapid repair of damaged muscle tissue following injury.
• Bone Healing: Accelerates the formation of new bone (osteogenesis) in fracture models.

3.2. Angiogenesis

Angiogenesis, the formation of new blood vessels, is a prerequisite for effective tissue repair. BPC-157 significantly promotes this process.

• Mechanism: Direct stimulation of the VEGFR2 pathway, leading to enhanced migration and proliferation of endothelial cells.
• Implication: Improved vascularization in damaged or ischemic tissues, accelerating the delivery of healing factors and clearance of metabolic waste.

3.3. Cytoprotection and Gastrointestinal Integrity

BPC-157 was originally studied for its cytoprotective effects, stemming from its natural origin in gastric juice.

• GI Mucosal Integrity: Provides significant protection against various forms of mucosal damage, including those induced by NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), alcohol, and stress.
• Systemic Cytoprotection: Research has expanded to investigate its protective effects on organs outside the GI tract, including the liver, pancreas, and brain, against toxin- or injury-induced damage.

4. Laboratory Usage and Safety

Disclaimer: This product is sold FOR LABORATORY RESEARCH USE ONLY. It is not intended for human consumption, therapeutic, or diagnostic purposes. The purchaser assumes all responsibility for testing, research, and safe usage in accordance with relevant regulatory guidelines.

4.1. Preparation

BPC-157 is typically supplied as a sterile, lyophilized powder. Reconstitution is necessary prior to use in laboratory experiments.

Solvent Recommendation

Bacteriostatic water, sterile water, or 0.9% saline solution.

Reconstitution Procedure

Introduce the solvent slowly down the side of the vial. Do not shake or agitate forcefully. Allow to dissolve completely, which may take several minutes.

Working Concentration

Determined by the specific research application.

4.2. Handling and Storage

Proper handling is essential to maintain the integrity and bioactivity of the peptide.

• Lyophilized State: Store at -20°C for optimal long-term stability. The product is stable at room temperature for short periods during shipping.
• Reconstituted Solution: Should be stored refrigerated (2-8°C) and used within Date to Date days. For longer storage, aliquot and freeze at -20°C or below. Avoid multiple freeze-thaw cycles.
• Safety Precautions: Standard laboratory protective equipment (gloves, lab coat, eye protection) must be worn during handling. Consult the provided Safety Data Sheet (File) for detailed hazard information.

5. Supporting Research References

This section lists a selection of recent peer-reviewed articles investigating the biological activities of BPC-157.

Reference Title

Journal/Source

Focus Area

BPC-157 Promotes Tendon and Ligament Healing

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Musculoskeletal Repair

The Role of Pentadecapeptide BPC-157 in Gastric Ulcer Healing

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Cytoprotection

BPC-157 and Angiogenesis: An In Vitro and In Vivo Study

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VEGFR2 Activation

Neuroprotective Effects of BPC-157 in CNS Injury Models

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Nervous System

6. Contact and Ordering Information

For technical inquiries, bulk orders, or to request a Certificate of Analysis (COA) for a specific lot number, please contact:

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